The 36th annual Niagara's 12 Mile Creek Trail Half Marathon & 7k Cancer Run takes place on June 7, 2025, in St. Catharines, Ontario. The half marathon course follows a historic route along the first Welland Canal featuring the scenic 12 Mile Creek Trail (also known as the Merritt Trail), including a challenging ascent up Hydro Hill on the Niagara Escarpment. The 7 km run offers a shorter but demanding trail experience. Proceeds support the Niagara Rankin Cancer Run.

- Supports Niagara Rankin Cancer Run charity
- Historic route along the first Welland Canal
- Scenic 12 Mile Creek Trail (Merritt Trail)
- Challenging Hydro Hill climb
- Multiple race distances: Half Marathon and 7 km trail run
- Limited to 275 total participants